Temperature Dependence of Protein Folding Deduced from Quantum Transition

Por • 25 feb, 2011 • Sección: Leyes

Liaofu Luo, Jun Lu

Abstract: A quantum theory on conformation-electron system is presented. Protein folding is regarded as the quantum transition between torsion states on polypeptide chain, and the folding rate is calculated by nonadiabatic operator method. The theory is used to study the temperature dependences of folding rate of 15 proteins and their non-Arrhenius behavior can all be deduced in a natural way. A general formula on the rate-temperature dependence has been deduced which is in good accordance with experimental data. These temperature dependences are further analyzed in terms of torsion potential parameters. Our results show it is necessary to move outside the realm of classical physics when the temperature dependence of protein folding is studied quantitatively.

 Link: http://arxiv.org/abs/1102.3748

Cite as: arXiv:1102.3748v1

Post to Twitter

Etiquetado con: , , , , , , ,

Escribe un comentario